I have global connections at 500, then there is another 300 or so coming from DHT, halfopen at 40. Never had any slowdown problems with regards to the router, seems to handle it quite well. I also pushed my old DGL-4300 pretty hard, had it at 800 global connections, even though people kept saying keep connections around 200.
I had some issues with lan errors on the router though, causing a connection drop, but I got that fixed when I changed my cat5e cables to cat6.